The 91th KARC Colloquium
The 91th KARC Colloquium was ended. Thank you for the participation.
| Date&Time | Tuesday, May 20th, 2008 14：00-15：00 |
| Place | Conference Room, 3F, Laboratory Bldg 2,Kobe Advanced ICT Research Center |
| Lecturer | “Single molecule detection of the two-legged nano-machine” |
| Speaker | Dr.So Nishikawa (Assistant Professor, Graduate School of Frontier Bioscience, Osaka Univ.) |
| Abstracts | All living organisms contain nano-machines: biomolecular motor proteins. We believe that exploring the unique operation of motor proteins will be the fastest path to the successful developmentof useful nanoscale devices.Biomolecular motor proteins of nanometer size are thus subject to Brownian motion. Such thermal effects become significant when the size of particles becomes small. Thermal energy makes many processes stochastic and influences the protein's dynamics. Further, many motor proteins run on energy liberated from the hydrolysis of ATP (adenosine tri-phosphate). This input energy level is only 20 times that of thermal energy while artificial and macroscopic machines which have input energy levels many orders of magnitude higher. Indeed, machines created by mankind are designed to work without disturbance from thermal noise. Motor proteins, however, are able to perform their functions effectively without being disturbed by thermal noise. How do proteins accomplish this task?To address this question, we have directly observed the dynamic behavior of biomolecular motor proteins using single molecule detection (SMD) technology. Before SMD was available, protein functions were examined using ensemble measurements from large numbers of molecules. The data were averaged over millions of molecules and stochastic processes and dynamic properties were hidden and obscured. The direct measurements of proteins' dynamic functions are only possible through SMD techniques. In the following, we survey our latest SMD experiments designed to investigate processive myosin motor, and discuss the mechanism of biomolecular nano-machines. |
| Language | Japanese |
| Admission | Free |
| Organizer | Hiroaki Kojima, Biological ICT group, Kobe Advanced ICT Research Center, NICT |