| Date&Time |
October, 28th, Thursday 14:00 〜 15:00 |
| Place |
TV conference room 1, _3F of Research Building 1 , Advanced ICT Kobe , NICT |
| Lecturer |
"The Metastable, Sponge-Like Centrosome Drives Liquid-Like Scaffold Expulsion" |
| Speaker |
Dr. Isaac Wong (Siu Shing Wong)Junior Research Fellow, University of Oxford
|
| Abstract |
The centrosome, consisting of a pair of centrioles surrounded by a pericentriolar material (PCM) matrix, serves as the primary microtubule-organizing center and is essential for diverse cellular functions. This membraneless organelle must strike a delicate balance: maintaining mechanical strength to resist microtubule-generated forces while retaining the flexibility to remodel or disassemble when needed. In Drosophila, two distinct PCM scaffolds have been described: a solid-like scaffold formed by Cnn and a liquid-like scaffold formed by TACC, both dependent on the core centrosomal protein Spd-2. Here, we uncover a more intricate interplay between these scaffolds. Our findings indicate that Cnn forms a porous, sponge-like network that supports the TACC scaffold by allowing microtubule forces to generate cavities within the solid-like matrix. During mitosis, compaction of the Cnn scaffold triggers a density-dependent displacement of the TACC scaffold away from the centrosome. This coordinated mechanism provides both mechanical resilience and dynamic adaptability, offering insight into how centrosomes?and potentially other membraneless organelles?achieve functional flexibility through the integration of solid- and liquid-like material properties. |
| Language |
English |
| Admission |
Free |
| Organizer |
FURUTA Kenya, Research Manager, Protein Biophysics Project, Bio-ICT Laboratory |
