The147th Advanced ICT Kobe Colloquium
The147th Advanced ICT Kobe Colloquium was ended. Thank you for the participation.
| Date&Time | October, 28th, Thursday 14:00 〜 15:00 |
| Place | TV conference room 1, _3F of Research Building 1 , Advanced ICT Kobe , NICT |
| Lecturer | "The Metastable, Sponge-Like Centrosome Balances Structural Stability and Dynamic Remodeling" |
| Speaker | Dr. Isaac Wong (Siu Shing Wong)Junior Research Fellow, University of Oxford |
| Abstract | The centrosome, composed of a pair of centrioles surrounded by a pericentriolar material (PCM) matrix, functions as the primary microtubule-organising centre and plays essential roles in cell architecture, division and signaling. Despite its lack of a membrane, the centrosome maintains a well-defined structure while undergoing dynamic remodelling throughout the cell cycle. How this organelle achieves both mechanical stability and adaptive flexibility remains an open question. Using Drosophila as a model system, we investigate how distinct molecular scaffolds within the PCM cooperate to balance rigidity with fluidity. Through quantitative imaging and biophysical analysis, we reveal that the centrosome exhibits properties of a metastable, sponge-like network capable of reorganizing in response to cellular forces and compositional changes. Our findings suggest that centrosome function emerges from the interplay of solid- and liquid-like material states, providing a general framework for understanding how membraneless organelles integrate mechanical and dynamic properties to support diverse cellular activities. |
| Language | English |
| Admission | Free |
| Organizer | FURUTA Kenya, Research Manager, Protein Biophysics Project, Bio-ICT Laboratory |