Background A method that promotes the retrieval of lost long-term memories has not been
well established. Histamine in the central nervous system is implicated in learning and
memory, and treatment with antihistamines impairs learning and memory. Because
histamine H 3 receptor inverse agonists upregulate histamine release, the inverse agonists
may enhance learning and memory. However, whether the inverse agonists promote the
retrieval of forgotten long-term memory has not yet been determined. Methods Here, we …