The use of free-space optical (FSO) systems as secure transmission media has recently attracted research efforts worldwide. However, their secrecy performance may be compromised by the presence of an adversarial eavesdropper. In addition, misalignments between transceivers could severely affect the legitimate FSO channel and increase eavesdropping risks. This paper, for the first time, offers a complete framework to analyze the impact of an eavesdropper's location on the secrecy performance of terrestrial FSO systems under generalized misalignments and atmospheric turbulence conditions. Particularly, the probability density functions (PDFs) of the eavesdropping channel are newly developed and presented in closed-form expressions. Capitalizing on the derived PDFs, secrecy performance metrics in the physical-layer security (PLS) and intensity modulation/direct detection (IM/DD) continuous-variable quantum key distribution (CV-QKD) systems can be analytically analyzed, incorporating all combined effects of the atmospheric turbulence, transceiver misalignments, receiver noises, and the eavesdropper's location. Monte-Carlo (MC) simulations are also implemented to corroborate the analytical results.