p62/SQSTM 1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

M Tsuchiya, H Ogawa, T Koujin, C Mori… - FEBS Open …, 2018 - Wiley Online Library
Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign
entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important
process in xenophagy but when and where this ubiquitination occurs remains unclear. Here,
we analyzed the temporal sequence and subcellular location of ubiquitination during
xenophagy using time‐lapse observations, with polystyrene beads mimicking invading
pathogens. Results revealed accumulation of a ubiquitination marker around the beads …

[CITATION][C] p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy. FEBS Open Bio 8, 470–480

M Tsuchiya, H Ogawa, T Koujin, C Mori, H Osakada… - 2018
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