タンパク質モータのナノ・マイクロデバイスへの応用 大岩和弘・米谷玲皇*・小嶋寛明 中森鈴奈・松井真二*・鈴木　仁 情報通信研究機構 関西先端研究センタ一　651−2492　兵庫県神戸市西区岩岡町岩岡 588−2 *兵庫県立大学 高度産業科学技術研究所　678−1205　兵庫県赤穂郡上郡町光都 3−1−2 （2004年10月20日受理） Application of Protein Motors to Nanometer-and Micrometer-scale Devices Kazuhiro OIWA, Reo KOMETANI*, Hiroaki KOJIMA, Rinna NAKAMORI, Shinji MATSUI*and Hitoshi SUZUKI Kansai Advanced Research Center, NICT, 5 88-2 Iwaoka, Nishi-ku,Kobe, Hyogo 651-2401 *University of Hyogo, Graduate School of Science, LASTI, 3-1-2 Koto, Kamigori-cho, Ako-gun, Hyogo 678-1205 (Received October 20,2004)

Protein motors are chemo-mechanical ATPases that can naturally generate force and move cargo or as individual mole-cules along tracks of protein polymers (actin filaments or microtubules), using chemical energy from adenosinetriphos-phate (ATP) hydrolysis. In order to harness these protein motors to power nanometer-scale devices, we have jnvestigated effective and non-destructive methods for immobilising them and/or their protein filament tracks on surfaces and to Steer the output of these motors, i.e.force and movement, into defined directions. We succeeded in aligning protein motors (myosin and its proteolytic fragments) on microscopic tracks composed of polytetrafluoroethylene (PTFE) deposited on the surfaces or polymethylmethacrylate (PMMA) prepared lithographically. Control of protein-motor driven movement of pro- tein filaments was successfully made by using micrometer-scale grooves or walls lithographically fabricated on glass sur-faces, and thus unidirectional movement of the flaments was accomplished by adding simple patterns onto the grooves or walls.