The035th KARC Colloquium
The035th KARC Colloquium was ended. Thank you for the participation.
| Date&Time | Monday December 22, 2003 13:30-14:30 |
| Place | TV conference room, 3F. Laboratory Bldg. No. 2, KARC |
| Lecturer | “Building the NanoAssembly Line” |
| Speaker | Dr. Bruce Paul Gabero The Center for Bio/Molecular Science & Engineering Naval Research Laboratory, USA |
| Abstract | n the opening years of the 20th Century Henry Ford revolutionized manufacturing with the introduction of the industrial assembly line. Almost 100 years later we shall demonstrate a shift in that paradigm by reducing the size of the assembly line by nine orders of magnitude. Kinesin motors drive our Nano-Assembly Line by moving microtubules along guiding channels. The microtubules carry multiple copies of an acylase. As the microtubules are moved along the channels, they pass “workstations that contain polymer-bound acyl-FTIC. The acylase cleaves the acyl block from the fluorophore revealing regions of fluorescence as the microtubules move along the assembly line. This is a proof-of-principle experiment designed to demonstrate the general concept of moving active cargos with biomolecular motors to bring about specific and highly localized chemical and physical transformations on a micron scale. In our presentation we will discuss the specific design and construction of the assembly line and describe its performance metrics. |
| Language | English |
| Admission | Free |
| Organizer | Kazuhiro OIWA Ph.D. Protein Biophysics Group Leader, KARC |