The 97th KARC Colloquium
The 97th KARC Colloquium was ended. Thank you for the participation.
| Date&Time | Thursday, 15 January 2009 13:30-14:30 |
| Place | TV Conference Room, 3F, Research Building 2,Kobe Advanced ICT Research Center |
| Lecturer | “DNA-templated assembly of multiple motor protein complex: toward an understanding of the collective dynamics of molecular machines” |
| Speaker | Dr. Ken-ya Furuta JSPS Research Fellow |
| Abstract | Recent studies using single-molecule techniques have revealed the detailed mechanisms of motor proteins as a molecular machine. It is apparent that understanding life processes requires detailed knowledge of the properties of individual elements which comprise a living organism. However, biosystems usually cannot be represented as a simple sum of individual elements; the elements themselves are biopolymers that have numerous degrees of freedom, and thus the interaction between these elements may well be readily affected by the whole system. This makes it difficult to deduce the behavior of the whole system from the properties of the elements, unlike machinery of a clock. In fact, molecular motors usually work in teams in vivo and therefore the question arises how these motors are coupled in multiple-molecule complexes. To squarely address this question, we need to go beyond the single-molecule techniques: a bottom-up, constructive approach is needed, in which the behavior of complex containing exactly one, two, three or more molecules can be observed, and then a model can be constructed to understand the underlying mechanisms. I will report the preliminary results obtained by using a novel approach that takes advantage of specific DNA hybridization to regulate the number of motors attached to a scaffold DNA. |
| Language | Japanese |
| Admission | Free |
| Organizer | Shiori Toba Ph.D. Research Scientist, Biological ICT groupKobe Advanced ICT Research Center, NICT |