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Strategic Basic Research Programs CREST


[Biodynamics] Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics


Research agenda
"Cell-cell adhesion・Elucidation of the mechanism of order formation of the skeleton and development of epithelial barrier manipulation technology"
Research period:October 2013 - March 2018
Principal Investigator:Tsukiko TSUKITA(Professor,Graduate School of Frontier Biosciences, Osaka University)
Research contributor : Kazuhiro OIWA

Outline / Purpose / Methods / Results

→Models Numerical
→Summary

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Numerical simulation of Eg5-MT network dynamics

κ=0.5, L=0.008, ι=0.08, c˜=0.5, ε=0.1, γ=1.0

Density: M = 0.1(Low)
Magnitude of contraction:K = 15
Speed of accumulation : f = 0.01
動画1
Static Network
stable structure with sparsely- distributed active nodes, where motors accumulated
M = 0.59 (Middle)
K = 15
f = 0.01
2
Active Network
Active nodes become interconnected to form a network contracting globally, resulting in the self-rupture.
M = 1.0 (High)
K = 15
f = 0.01
3
Aggregation
The active nodes pull the surrounding nodes to form a chain-like assembly.
M = 1.0 (High)
K = 45
f = 5
4
Asters
Rapid separation into many isolated asters. This simulation resembles the pattern generated by chimera motors

→Results
→Summary

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