主要論文
Sakurai, A., Littleton, J. T. Hiroaki Kojima, H. and Yoshihara, MAlteration in information flow through a pair of feeding command neurons underlies a form of Pavlovian conditioning in the Drosophila brain, Curr. Biol. (2021) 31, 4163-4171.
https://doi.org/10.1016/j.cub.2021.07.021
Fujii, T., Sakurai, A., Littleton, J.T., Yoshihara, M.
Synaptotagmin 7 switches short‑term synaptic plasticity from depression to facilitation by suppressing synaptic transmission. Sci. Rep. (2021) 11: 4059
Yoshihara, M.* and Yoshihara, Motoyuki
‘Necessary and sufficient’ in biology is not necessarily necessary – confusions and erroneous conclusions resulting from misapplied logic in the field of biology, especially neuroscience.
J NEUROGENET (2018) 32: 53-62. *Corresponding author.
doi.org/10.1080/01677063.2018.1468443.
Nature社説により紹介 (Nature, 558: 162, 2018)
「必要かつ十分」という語句の誤用をなくすべきだ | Nature ダイジェスト | Nature Portfolio (natureasia.com)
Flood, T., Gorczyca, M., White, B., Ito, K. and Yoshihara, M.*
A large-scale behavioral screen to identify neurons controlling motor programs in the Drosophila brain.
G3: Genes, Genomes, Genetics (2013) 3: 1679-1637. *Corresponding author.
Flood, T.§, Iguchi, S. §, Gorczyca, M. §, White, B., Ito, K. and Yoshihara, M. *
A single pair of interneurons commands the Drosophila feeding motor program.
Nature (2013) 499: 83-87. *Corresponding author. §Equal contribution
Korkut, C, Li, Y, Koles, K, Brewer, C, Ashley, J, Yoshihara, M, Budnik, V.
Regulation of postsynaptic retrograde signaling by presynaptic exosome release. Neuron (2013) 77: 1039-46.
Yoshihara, M.
Simultaneous recording calcium signals from identified neurons and feeding behavior in Drosophila melanogaster. Journal of Visualized Experiments (2012) 62: e3625, DOI: 10.3791/3625.
Yoshihara, M.*, Guan, Z. and Littleton , J.T.
Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.
Proc. Natl. Acad. Sci. USA (2010) 107: 14869-14874 *Corresponding author.
Yoshihara, M.*, Adolfsen, B., Galle, K.T. and Littleton, J.T.
Retrograde signaling by Synaptotagmin 4 induces presynaptic release and synapse-specific growth.
Science (2005) 310: 858-863 *Corresponding author.
Adolfsen, B., Saraswati, S., Yoshihara, M. and Littleton, J.T.
Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment.
J. Cell Biol. (2004) 166: 249-260
Lee, W.C., Yoshihara, M. and Littleton, J.T.
Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.
Proc. Natl. Acad. Sci. USA (2004) 101: 3224-3229
Reickhof, G.E., Yoshihara, M., Guan, Z. and Littleton, J.T.
Presynaptic N-type calcium channels regulate synaptic growth.
J. Biol. Chem. (2003) 278: 41099-41108
Yoshihara, M. * and Littleton, J.T.
Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.
Neuron (2002) 36: 897-908 *Corresponding author.
Hayashi, S., Ito, K. Sado, Y., Taniguchi, M., Akimoto, A., Takeuchi, H., Aigaki, T., Matsuzaki, F., Nakagoshi, H., Tanimura, T., Ueda, R., Uemura, T., Yoshihara, M. and Goto. S. (2002)
GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps. Genesis 34: 58-61.
Takasu-Ishikawa, E.*, Yoshihara, M.*, Ueda, A., Rheuben, M. B., Hotta, Y. and Kidokoro, Y.
Screening for synaptic defects revealed a locus involved in presynaptic and postsynaptic functions in Drosophila embryos.
J. Neurobiol. (2001) 48: 101-119 * Equal contribution.
Yoshihara, M., Suzuki, K. and Kidokoro, Y.
Two independent pathways mediated by cAMP and protein kinase A enhance spontaneous transmitter release at Drosophila neuromuscular junctions.
J. Neurosci. (2000) 20: 8315-8322
Yoshihara, M., and Ito, K.
Improved Gal4 screening kit for large-scale generation of enhancer-trap strains.
Dros. Inf. Ser. (2000) 83: 199-202.
Yoshihara, M., Ueda, A., Zhang, D., Deicher, D. L., Schwarz, T.L. and Kidokoro, Y.
Selective effects of neuronal-synaptobrevin mutations on transmitter release evoked by sustained versus transient Ca2+ increases and by cAMP.
J. Neurosci. (1999) 19: 2432-2441
Yoshihara, M., Rheuben, M. B. and Kidokoro, Y.
Transition from growth cone to functional motor nerve terminal in Drosophila embryos.
J. Neurosci. (1997) 17: 8408-8426
英語総説
Yoshihara M. *, Ito K.Acute genetic manipulation of neuronal activity for the functional dissection of neural circuits-a dream come true for the pioneers of behavioral genetics.
J. Neurogenet. 26 (2012) 43-52. *Corresponding author.
Yoshihara, M. * and Montana, E.S.
The Synaptotagmins: Calcium Sensors for Vesicular Trafficking.
The Neuroscientist 10 (2004) 566-574. *Corresponding author.
Yoshihara, M., Adolfsen, B. and Littleton, J.T.
Is synaptotagmin the calcium sensor?
Current Opinions in Neurobiology 13 (2003) 315-323.
Yoshihara, M., Ensminger , A. and Littleton, J. T.
Neurobiology and the Drosophila genome.
Functional & Integrative Genomics 1 (2001) 235-240.
日本語総説
吉原基二郎Ivan Petrovich Pavlov (1904) 条件反射を "発見" した, 記憶神経生物学の先駆者
Clinical Neuroscience 2022年 Vol. 40 (8) 928-933, 中外医学社
吉原基二郎
“necessary & sufficient”に気をつけてー若き生命科学者の健全な思考法のために－
実験医学 Trend Review 2019年 Vol.37 No.4 （3月号）571-578 羊土社
吉原基二郎
神経活動の遺伝学的な制御とコマンドニューロン
実験医学 2013年 Vol. 31, No. 19 (12月号) 3098-3102 羊土社
吉原基二郎
“To eat or not to eat. That is the question”: ショウジョウバエ摂食行動のコマンドニューロン
細胞工学 2013年 32巻９月号 986-987 学研メディカル秀潤社
吉原基二郎
シナプスの可塑性と記憶の形成とを結ぶショウジョウバエの摂食行動に関わるコマンドニューロン
ライフサイエンス新着論文レビュー 2013年
(http://first.lifesciencedb.jp/archives/7415#more-7415)